DOMINIQUE HEYMANN
BONE CANCER
(UNG THƯ XƯƠNG)
PUBLISHER: ELSEVIER ACADEMIC PRESS (2010)
THÔNG TIN CHUNG:
Tên sách: Bone Cancer (tạm dịch: Ung thư xương).
Tác giả: Dominique Heymann.
NXB: Elsevier Academic Press (2010).
Thông số: 457 trang - 42 chương chính.
Ung thư xương là một trong những căn bệnh ung thư nguy hiểm, bệnh diễn tiến âm thầm và cướp đi sinh mạng của nhiều người; thông thường ung thư xương là do di căn từ các bộ phận ung thư khác. Cuốn sách này là những đúc kết kiến thức và kinh nghiệm sâu sắc nhất trong chẩn đoán và điều trị căn bệnh này, rất phù hợp đối với các học viên cũng như chuyên gia trong chuyên ngành có nhu cầu tiếp thu những kiến thức tiên tiến nhất. Sách bản đẹp, mục lục tự động, dung lượng nhỏ gọn, tương thích tốt với các thiết bị cầm tay.
INTRODUCTION (GIỚI THIỆU):
The past decade has witnessed an explosion in the field of bone biology. The topic of bone biology over this period has been marked by significant advances that have opened up entirely new areas for investigation. Indeed, the molecular mechanisms that control bone remodeling have been exten-sively investigated and some scientific fields have emerged. This is the case for osteoimmunology after identification of a set of molecules, allowing communication between bone cells (ostoclasts, osteoblasts) and immune cells (monocytes, lymphocytes, dendritic cells). Similarly, concepts based on the neuronal regulation of bone mass have emerged. Unfortunately, genetic or environmental deregulations lead to the development of bone cancer diseases such as primary bone tumors (osteosarcoma, Ewing’s sarcoma, chondrosar-comas, giant cell tumors, etc.) that originate from bone cells or from mesenchymal stem cells. Bone is also a privileged site for metastases due to the migration and development of tumor cells derivating from non-bone cells such as breast cancer cells or prostate carcinomas cells. Some tumor cells such as myeloma cells initially proliferate in bone sites and then induce a deregulation of the bone apposition and resorption balance in favor of an osteolytic process.
This book gives an overview of the most up-to-date epidemiological data of these tumors and their biology includ-ing molecular aspects (protein and gene) allowing clear identification of new therapeutic targets and approaches. As well as the biological aspects of bone tissue, primitive bone tumors and bone metastases well described in this book, the clinical aspects are also addressed: histopathol-ogy, imaging of bone tumors, management of bone pain and conventional therapeutic care. Finally, better understand-ing of biological mechanisms associated with the develop-ment of many pre-clinical models allows the emergence of new therapeutic approaches of bone tumors. Therefore, this book, describing bone tumors, from their fundamental aspects to their clinical aspects, is specifically dedicated to medical students and scientists, to health professionals, researchers and teachers working in the osteo-articular domain and interested in the more recent data available. This review book consists of 38 chapters resulting from the work of 26 professional teams from 11 countries and who are specializing in the pathophysiology of bone. I would like to thank the authors for the work performed and to give their expertise to the students, to our colleagues and to all readers.
TABLE OF CONTENTS (MỤC LỤC):
Section I: Epidemiology and Economical Aspects of Bone Cancer
Section II: Bone Microenvironment and Bone Cancer
Section III: Bone Markers of Cancer (Genes and Proteins)
Section IV: Histopathology of Primary Bone Tumors and Bone Metastases
Section V: Imaging of Bone Cancer
Section VI: Pain Control in Bone Cancer
Section VII: New Therapeutic Advances in Primary Bone Cancers and Bone Metastases
TABLE OF CONTENTS (MỤC LỤC):
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