Gideon M. Hirschfield - E. Jenny Heathcote
AUTOIMMUNE HEPATITIS
(VIÊM GAN TỰ MIỄN)
PUBLISHER: SPINGER (2012)
THÔNG TIN CHUNG:
Tiêu đề: Autoimmune Hepatitis (tạm dịch: Viêm gan tự miễn).
Tác giả: Gideon M. Hirschfield.
NXB: Humana Press (2012).
Thông số: 254 trang - 13 chương chính.
Viêm gan tự miễn là một bệnh gan dạng viêm hoại tử chưa giải quyết được, đặc trưng bởi một đáp ứng miễn dịch trực tiếp chống lại mô gan, dẫn đến sự hủy hoại nhu mô gan. Các chất chỉ điểm trong huyết thanh miễn dịch thường hiện diện, và bệnh thường tồn tại cùng với các rối loạn tự miễn khác kèm theo. Cuốn sách này sẽ là cẩm nang hữu ích cho quý độc giả đặc biệt là các học viên, chuyên gia trong ngành; Cung cấp kiến thức chi tiết về bệnh viêm gan tự miễn, các phương pháp chẩn đoán và điều trị tiên tiến nhất trên thế giới. Sách bản đẹp, mục lục tự động, tương thích tốt với hầu hết các thiết bị đọc hiện nay.
INTRODUCTION (GIỚI THIỆU):
Autoimmune hepatitis is a relatively rare chronic infl ammatory disease of the liver, which is seen in adults and children, women and men, and across the world. It remains somewhat of a curiosity given the lack of specifi c diagnostic tests. Nevertheless, a pattern of clinical and laboratory presentation, coupled with an absence of alternative etiologies, remains a reliable way for clinicians to identify patients with this disease. Untreated mortality is high from severe disease, but fortunately immunosuppression with steroids and azathioprine in particular is very effective, and the outcomes for patients are now excellent, given appropriate diagnosis and prompt treatment. Nevertheless, with the recognized side effects of treatment it remains important for clinicians to be confi dent in their diagnosis, and to have clear strategies for how they manage their patients over the long term.
With this in mind we set out to write a clinically useful textbook on autoimmune hepatitis, which hopefully addresses the common concerns encountered in routine practice. We have collected expert opinion from North America and Europe, which jointly collates evidence and practice into one readily accessible volume. Dr. Vierling initiates with a stimulating discussion of the pathogenesis of disease, while Dr. Heathcote reviews patient presentation in the twenty-fi rst century, something that continues to evolve. The use of serology in the diagnosis of disease is then reviewed by Dr. Bogdanos, whose chapter helps clinicians appreciate the benefi ts and limitations of autoim-mune serology. Dr. Michael Manns and Dr. Arndt Vogel provide some biologic insights into mimics of disease, while very practical guidance from expert adult (Dr. Montano-Loza) And pediatric (Dr. Mieli-Vergani and Dr. Vergani) Clinicians is presented. Given that there are nuances to care, further insights into strategies for treatment nonresponders is provided by Dr. Peters and Dr. Mileti. Dr. Neuberger gives the perspective of the Transplant Hepatologist, since patients, despite adequate treatment, may still need the life-saving benefi ts of transplantation, while Dr. Heneghan and Dr. Westbrook help clinicians with the issues raised for patients contemplating pregnancy. Finally, two important chapters conclude this book, the first by Dr. Levy, addressing side effects, and the second by Dr. Boberg, who tackles the often confus-ing but important area of overlap syndromes.
Readers will therefore see that in assembling this group of authors the editors have set out to provide the breadth of opinion and knowledge that exists on the present day management of autoimmune hepatitis. It remains our hope that this book therefore fi lls an important niche for those looking after patients with autoimmune hepatitis.
TABLE OF CONTENTS (MỤC LỤC):
Chapter 1: Introduction
Chapter 2: The Pathogenesis of Autoimmune Hepatitis
Chapter 3: Clinical Presentation
Chapter 4: Confirmation of the Diagnosis: Interpreting the Serology
Chapter 5: Mimics of Autoimmune Hepatitis: Drug Induced and Immune Mediated Liver Disease
Chapter 6: When and How to Treat the Adult Patient
Chapter 7: When and How to Treat the Pediatric Patient
Chapter 8: Strategies for Treatment Nonresponders: Second-Line Therapies and Novel Approaches
Chapter 9: Liver Transplantation for Autoimmune Hepatitis
Chapter 10: Autoimmune Hepatitis and Pregnancy
Chapter 11: Treatment Side Effects and Associated Autoimmune Diseases
Chapter 12: Managing the Patient with Features of Overlapping Autoimmune Liver Disease
Chapter 13: Autoimmune Hepatitis: A Look Toward the Future
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