Giáo trình Y học: Advanced Topics in Neurological Disorders (Chuyên đề cấp cao về chứng rối loạn thần kinh)

KEN-SHIUNG CHEN

ADVANCED TOPICS IN NEUROLOGICAL DISORDERS

(CHUYÊN ĐỀ CẤP CAO VỀ CHỨNG RỐI LOẠN THẦN KINH)

PUBLISHER: INTECH (2012)

THÔNG TIN CHUNG:

Tiêu đề: Advanced Topics in Neurological Disorders (tạm dịch: Chuyên đề cấp cao về chứng rối loạn thần kinh)

Tác giả: Ken-Shiung Chen

NXB: InTech (2012)

Cuốn sách được chia làm 3 phần, 9 chương sẽ trình bày chi tiết cho người đọc về các chứng rối loạn thần kinh theo các chuyên đề cao cấp tại các trường đại học và bệnh viện trên toàn thế giới. Qua đó, các nhà nghiên cứu và các y bác sĩ sẽ có được những kinh nghiệm quý giá về các hội chứng nan giải trong chuyên ngành thần kinh học.

INTRODUCTION (GIỚI THIỆU):

The study of our brain and associated neurological disorders represent one of the most fascinating frontiers in the biomedical sciences. Recent research studies using multidisciplinary approaches not only provide a molecular understanding of disease mechanisms but also suggest novel tools for therapeutic interventions. Advanced Topics in Neurological Disorders presents reports on a wide range of areas in the field of neurological disorders, including bioengineering, stem cell transplantation, gene therapy, proteomic analysis, and alternative treatments to neuropsychiatry illnesses.

Chapter 1 presents a review of the history of the bionic eye and provides an update on the current state and future prospects of the field. Chapter 2 describes an accurate method for the simultaneous evaluation of the eye, head and shoulder positions in neurological practice. Possible applications and perspectives for clinical practice are also described in the chapter. Chapter 3 provides a review for the clinical application of using mesenchymal stem cells to treat brain injury. Ongoing clinical trials, issues of delivery timing, route and donor source, dosage and mechanisms of action underlying beneficial effects are discussed. Chapter 4 provides a review for the use of foamy virus vector as a carrier to deliver therapeutic genes for neurological disorders and other diseases. Chapter 5 presents a review of existing methods to extract the morphology of intracranial pressure (ICP). A novel probabilistic framework to track the ICP morphology in real time is introduced and a successful study for the real-time prediction of ICP hypertension is described. Chapter 6 introduces methods for protein analysis and profiling techniques in clinical practice, and further discusses the application of new methods for cerebrospinal fluid analysis as a primary biological media for the study of neurological diseases.

Chapter 7 describes the use of a proteomic approach to study the Angelman syndrome (AS) Mouse model. The results indicate that proteins involved in neuronal cell differentiation, learning processes, energy production, actin disassembly and neuronal signal transduction are affected in AS. Chapter 8 discusses the molecular basis, metabolites, biomarkers, triggers and polymorphisms associated with migraines. This chapter further discusses the pharmacotherapy for migraines and the effects of herbal medicine in migraine treatments. Chapter 9 argues that substance dependence should be considered a brain disease associated with cellular and neurocircuitry dysfunction. This review compares the relationship between anatomical and functional changes in the prefrontal cortex, executive abilities, and substance dependence by describing this relationship across multiple classes of drugs and polysubstance dependence.

TABLE OF CONTENTS (MỤC LỤC):

Preface

Part 1 Bioengineering in Neurological Disorders

Chapter 1 Image Analysis for Automatically-Driven Bionic Eye

Chapter 2 Methods of Measurement and Evaluation of Eye, Head and Shoulders Position in Neurological Practice

Chapter 3 Mesenchymal Stromal Cells to Treat Brain Injury

Chapter 4 Development of Foamy Virus Vectors for Gene Therapy for Neurological Disorders and Other Diseases

Chapter 5 Real-Time Analysis of Intracranial Pressure Waveform Morphology

Part 2 Proteomic Analysis in Neurological Disorders

Chapter 6 Developing Novel Methods for Protein Analysis and Their Potential

Implementation in Diagnosing Neurological Diseases

Chapter 7 Angelman Syndrome: Proteomics Analysis of an UBE3A Knockout Mouse and Its Implications

Part 3 Migraine and the Use of

Herbal Medicine as an Alternative Treatment

Chapter 8 Migraine: Molecular Basis and Herbal Medicine

Part 4 Neuropsychiatry of Drug and Alcohol Dependence

Chapter 9 Substance Dependence as a Neurological Disorder

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